NPLOC4 antibody (N-Term)

Catalog No. ABIN2789102

Product Details anti-NPLOC4 Antibody

Target: NPLOC4 (Nuclear Protein Localization 4 Homolog (NPLOC4))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Horse, Rabbit, Zebrafish (Danio rerio), Cow, Dog, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NPLOC4 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: GLKAFGAPNV VEDEIDQYLS KQDGKIYRSR DPQLCRHGPL GKCVHCVPLE

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 86%

Characteristics: This is a rabbit polyclonal antibody against Nploc4. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Mouse Nploc4

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 608 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for NPLOC4

Target: NPLOC4 (Nuclear Protein Localization 4 Homolog (NPLOC4))

Alternative Name: Nploc4 (NPLOC4 Products)

Synonyms: NPL4 antibody, AK129375 antibody, Npl4 antibody, mKIAA1499 antibody, NPL4 homolog, ubiquitin recognition factor antibody, NPLOC4 antibody, Nploc4 antibody

Background: The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope.
Alias Symbols: AK129375, Npl4, mKIAA1499
Protein Interaction Partner: Map3k1, Vcp, Ubc, Itpr1,
Protein Size: 608

Molecular Weight: 66 kDa

Gene ID: 217365

NCBI Accession: NM_001195023, NP_001181952

UniProt: P60670