CD33 antibody (N-Term)

Catalog No. ABIN2789356

The Rabbit Polyclonal anti-CD33 antibody is suitable to detect CD33 in samples from Human, Cow and Horse. It has been validated for WB.

Quick Overview for CD33 antibody (N-Term) (ABIN2789356)

Target: CD33

Reactivity: Human, Cow, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD33 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CD33 Antibody

Binding Specificity: N-Term

Purpose: CD33 Antibody - N-terminal region

Sequence: HPIPYYDKNS PVHGYWFREG AIISRDSPVA TNKLDQEVQE ETQGRFRLLG

Predicted Reactivity: Cow: 79%, Horse: 79%, Human: 100%

Characteristics: This is a rabbit polyclonal antibody against CD33. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP63067-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for CD33

Target: CD33

Alternative Name: CD33

Background:

Background Information: CD33 is a putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. CD33 preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, CD33 may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. CD33 induces apoptosis in acute myeloid leukemia (in vitro).

Gene Name: CD33 Molecule

Alternative Symbols: p67, SIGLEC3, SIGLEC-3

Protein Name: Myeloid cell surface antigen CD33

Molecular Weight: 38kDa

Gene ID: 945

NCBI Accession: NP_001763

UniProt: P20138