L1CAM antibody (C-Term)

Catalog No. ABIN2789372

This Rabbit Polyclonal antibody specifically detects L1CAM in WB. It exhibits reactivity toward Human, Mouse, Rat, Zebrafish (Danio rerio), Dog, Rabbit, Guinea Pig, Horse and Cow.

Quick Overview for L1CAM antibody (C-Term) (ABIN2789372)

Target: L1CAM (L1 Cell Adhesion Molecule (L1CAM))

Reactivity: Human, Mouse, Rat, Zebrafish (Danio rerio), Dog, Rabbit, Guinea Pig, Horse, Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This L1CAM antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-L1CAM Antibody

Binding Specificity: C-Term

Purpose: L1CAM Antibody - C-terminal region

Sequence: GDIKPLGSDD SLADYGGSVD VQFNEDGSFI GQYSGKKEKE AAGGNDSSGA

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against L1CAM. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP63103-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for L1CAM

Target: L1CAM (L1 Cell Adhesion Molecule (L1CAM))

Alternative Name: L1CAM

Background:

Background Information: The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of a neuron-specific exon is thought to be functionally relevant.

Gene Name: L1 cell adhesion molecule

Alternative Symbols: S10, HSAS, MASA, MIC5, SPG1, CAML1, CD171, HSAS1, N-CAML1, NCAM-L1, N-CAM-L1

Protein Name: Neural cell adhesion molecule L1

Molecular Weight: 140 kDa

Gene ID: 3897

NCBI Accession: NP_000416

UniProt: P32004

Pathways: Synaptic Membrane