HTRA1 antibody (N-Term)

Catalog No. ABIN2789539

This Rabbit Polyclonal antibody specifically detects HTRA1 in WB and IHC. It exhibits reactivity toward Human, Mouse, Rat, Cow and Pig.

Quick Overview for HTRA1 antibody (N-Term) (ABIN2789539)

Target: HTRA1 (HtrA Serine Peptidase 1 (HTRA1))

Reactivity: Human, Mouse, Rat, Cow, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HTRA1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-HTRA1 Antibody

Binding Specificity: N-Term

Sequence: DANTYANLCQ LRAASRRSER LHRPPVIVLQ RGACGQGQED PNSLRHKYNF

Predicted Reactivity: Cow: 100%, Human: 100%, Mouse: 92%, Pig: 100%, Rat: 92%

Characteristics: This is a rabbit polyclonal antibody against HTRA1. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 480 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for HTRA1

Target: HTRA1 (HtrA Serine Peptidase 1 (HTRA1))

Alternative Name: HTRA1

Background: This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. Variations in the promoter region of this gene are the cause of susceptibility to age-related macular degeneration type 7.
Alias Symbols: ARMD7, HtrA, L56, ORF480, PRSS11
Protein Interaction Partner: FAM46A, IMPDH1, CSNK2B, NOS3, APOE, XIAP, PARD6B, LRP10, FCHSD2, CDYL, COX5A, GOLGA2, GDF5, COL3A1, COL1A1, COL2A1, CAST, BMP4,
Protein Size: 480

Molecular Weight: 53 kDa

Gene ID: 5654

NCBI Accession: NM_002775, NP_002766

UniProt: Q92743

Pathways: Growth Factor Binding