HRPT2 antibody (C-Term)

Catalog No. ABIN2789576

Product Details anti-HRPT2 Antibody

Target: HRPT2 (CDC73) (Parafibromin (CDC73))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HRPT2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: KFVPSDEKKK QGCQRENETL IQRRKDQMQP GGTAISVTVP YRVVDQPLKL

Predicted Reactivity: Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 77%

Characteristics: This is a rabbit polyclonal antibody against CDC73. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 531 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for HRPT2

Target: HRPT2 (CDC73) (Parafibromin (CDC73))

Alternative Name: CDC73 (CDC73 Products)

Background: This gene encodes a tumor suppressor that is involved in transcriptional and post-transcriptional control pathways. The protein is a component of the the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A and with a histone methyltransferase complex. This protein appears to facilitate the association of 3' mRNA processing factors with actively-transcribed chromatin. Mutations in this gene have been linked to hyperparathyroidism-jaw tumor syndrome, familial isolated hyperparathyroidism, and parathyroid carcinoma
Alias Symbols: C1orf28, FLJ23316, HPTJT, HRPT2, HYX
Protein Interaction Partner: CCDC155, FSD2, TSGA10, CEP70, VPS37B, MTUS2, UBC, TFCP2, GOLGA2, ALAS1, CIAO1, AURKB, GPRASP2, COG3, MYH14, MYL12A, ARFGEF2, NUP98, MYH9, CHUK, DNMT3B, DNMT3A, SOX2, BCL9L, PAF1, CTR9, TCF4, CTNNB1, LEO1, GTF2F1, SUV39H1, PTPN11, WDR61, HIST1H3A, RNF20, R
Protein Size: 531

Molecular Weight: 58 kDa

Gene ID: 79577

NCBI Accession: NM_024529, NP_078805

UniProt: Q6P1J9

Pathways: Cellular Response to Molecule of Bacterial Origin, Stem Cell Maintenance