PLAU antibody (C-Term)

Catalog No. ABIN2789605

This anti-PLAU antibody is a Rabbit Polyclonal antibody detecting PLAU in WB. Suitable for Human, Rabbit, Horse and Saccharomyces cerevisiae.

Quick Overview for PLAU antibody (C-Term) (ABIN2789605)

Target: PLAU (Plasminogen Activator, Urokinase (PLAU))

Reactivity: Human, Rabbit, Horse, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLAU antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PLAU Antibody

Binding Specificity: C-Term

Sequence: CSLQGRMTLT GIVSWGRGCA LKDKPGVYTR VSHFLPWIRS HTKEENGLAL

Predicted Reactivity: Horse: 86%, Human: 100%, Rabbit: 86%, Yeast: 100%

Characteristics: This is a rabbit polyclonal antibody against PLAU. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 431 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PLAU

Target: PLAU (Plasminogen Activator, Urokinase (PLAU))

Alternative Name: PLAU

Background: This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor.
Alias Symbols: ATF, UPA, URK, u-PA, QPD, BDPLT5
Protein Interaction Partner: TEX101, UBC, PLAUR, SUMO1, NEDD8, CEBPG, ELAVL1, MYC, BTK, ALAS1, SCAMP5, PDGFC, ST14, SERPINA5, LRP2, SERPINF2, F2, SERPINB2, PLAT, SERPINE1, PLG, SERPINB6, IGF2R, HGF, NID1, CTSL, CTSB, MAP2K1, HRAS, SERPINE2,
Protein Size: 431

Molecular Weight: 28 kDa

Gene ID: 5328

NCBI Accession: NM_002658, NP_002649

UniProt: P00749

Pathways: Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Autophagy, Smooth Muscle Cell Migration