KIR2DS2 antibody (N-Term)

Catalog No. ABIN2789655

The Rabbit Polyclonal anti-KIR2DS2 antibody is suitable to detect KIR2DS2 in samples from Human. It has been validated for WB.

Quick Overview for KIR2DS2 antibody (N-Term) (ABIN2789655)

Target: KIR2DS2 (Killer Cell Immunoglobulin-Like Receptor 2DS2 (KIR2DS2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KIR2DS2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-KIR2DS2 Antibody

Binding Specificity: N-Term

Purpose: KIR2DS2 Antibody - N-terminal region

Sequence: ETVILQCWSD VRFEHFLLHR EGKYKDTLHL IGEHHDGVSK ANFSIGPMMQ

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against KIR2DS2. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP63891-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for KIR2DS2

Target: KIR2DS2 (Killer Cell Immunoglobulin-Like Receptor 2DS2 (KIR2DS2))

Alternative Name: KIR2DS2

Background:

Background Information: Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules, thus, KIR proteins are thought to play an important role in regulation of the immune response.

Gene Name: Killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2

Alternative Symbols: NKAT5, cl-49, CD158J, CD158b, NKAT-5, 183ActI, KIR2DL1, KIR-2DS2

Protein Name: KIR2DS2 EMBL ACX71621.1

Molecular Weight: 32kDa

Gene ID: 100132285

NCBI Accession: NP_036444

UniProt: D0UWM7