DIAPH1 antibody (C-Term)

Catalog No. ABIN2789663

Product Details anti-DIAPH1 Antibody

Target: DIAPH1 (Diaphanous Homolog 1 (DIAPH1))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Dog, Cow, Rabbit, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DIAPH1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: TGVMDSLLEA LQSGAAFRRK RGPRQANRKA GCAVTSLLAS ELTKDDAMAA

Predicted Reactivity: Cow: 85%, Dog: 100%, Human: 100%, Mouse: 93%, Pig: 92%, Rabbit: 86%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against DIAPH1. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1272 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for DIAPH1

Target: DIAPH1 (Diaphanous Homolog 1 (DIAPH1))

Alternative Name: DIAPH1 (DIAPH1 Products)

Background: This gene is a homolog of the Drosophila diaphanous gene, and has been linked to autosomal dominant, fully penetrant, nonsyndromic sensorineural progressive low-frequency hearing loss. Actin polymerization involves proteins known to interact with diaphanous protein in Drosophila and mouse. It has therefore been speculated that this gene may have a role in the regulation of actin polymerization in hair cells of the inner ear. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Alias Symbols: DFNA1, DIA1, DRF1, FLJ25265, LFHL1, hDIA1
Protein Interaction Partner: UBC, IQGAP1, WWOX, SMEK2, PRPF40A, PTPN23, COPZ1, WBP4, TCERG1, GAS7, NEDD4, KLC1, KIF5B, COPB1, ARCN1, APBB1, KLC4, UBD, gag-pol, VCAM1, GRB2, FN1, CENPA, HSPA4L, MYO1E, DCAF7, SRGAP2, XPO6, CDC7, PAX6, BAIAP2, RAC1, PKD2, RHOA, RHOC,
Protein Size: 1272

Molecular Weight: 141 kDa

Gene ID: 1729

NCBI Accession: NM_005219, NP_005210

UniProt: O60610

Pathways: Sensory Perception of Sound