CD276 antibody (C-Term)

Catalog No. ABIN2789671

This Rabbit Polyclonal antibody specifically detects CD276 in WB. It exhibits reactivity toward Human, Mouse, Rat, Horse, Cow, Rabbit, Dog, Pig and Guinea Pig.

Quick Overview for CD276 antibody (C-Term) (ABIN2789671)

Target: CD276

Reactivity: Human, Mouse, Rat, Horse, Cow, Rabbit, Dog, Pig, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD276 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CD276 Antibody

Binding Specificity: C-Term

Purpose: CD276 Antibody - C-terminal region

Sequence: VCLIALLVAL AFVCWRKIKQ SCEEENAGAE DQDGEGEGSK TALQPLKHSD

Predicted Reactivity: Cow: 86%, Dog: 93%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 93%, Rabbit: 86%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against CD276. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP63929-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for CD276

Target: CD276

Alternative Name: CD276

Background:

Background Information: The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene Name: CD276 Molecule

Alternative Symbols: B7H3, B7-H3, B7RP-2, 4Ig-B7-H3

Protein Name: CD276 antigen

Molecular Weight: 34kDa

Gene ID: 80381

NCBI Accession: NP_079516

UniProt: Q5ZPR3

Pathways: Cancer Immune Checkpoints