PICALM antibody (Middle Region)

Catalog No. ABIN2789681

Product Details anti-PICALM Antibody

Target: PICALM (Phosphatidylinositol Binding clathrin Assembly Protein (PICALM))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PICALM antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: ALEQHLASLE GKKIKDSTAA SRATTLSNAV SSLASTGLSL TKVDEREKQA

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against PICALM. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 652 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PICALM

Target: PICALM (Phosphatidylinositol Binding clathrin Assembly Protein (PICALM))

Alternative Name: PICALM (PICALM Products)

Synonyms: LAP-3 antibody, PEPS antibody, CALM antibody, CLTH antibody, LAP antibody, PAP180 antibody, fit-1 antibody, fit1 antibody, mKIAA4114 antibody, Calm antibody, leucine aminopeptidase 3 antibody, phosphatidylinositol binding clathrin assembly protein antibody, si:ch211-200p22.4 antibody, LAP3 antibody, PICALM antibody, Picalm antibody, si:ch211-200p22.4 antibody

Background: This gene encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. The protein is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. A chromosomal translocation t(10,11)(p13,q14) leading to the fusion of this gene and the MLLT10 gene is found in acute lymphoblastic leukemia, acute myeloid leukemia and malignant lymphomas. The polymorphisms of this gene are associated with the risk of Alzheimer disease.
Alias Symbols: CALM, CLTH, LAP
Protein Interaction Partner: UBC, PELI2, VCAM1, ITGA4, FN1, SIRT1, ILF3, EGFR, EEF1A1, DNM2, CD55, ABCC2, ATP6V1E1, AP2A1, SH3GLB2, FLOT1, HNRNPDL, SEC24D, SEC24C, ATP6V1F, HIP1R, LAMTOR3, ITSN1, EHD2, CASP8, CLTCL1, CASP3, PLCG1, DDIT3, CLTC,
Protein Size: 652

Molecular Weight: 71 kDa

Gene ID: 8301

NCBI Accession: NM_007166, NP_009097

UniProt: Q13492

Pathways: Synaptic Membrane