PDE11A antibody (C-Term)

Catalog No. ABIN2789717

This Rabbit Polyclonal antibody specifically detects PDE11A in WB. It exhibits reactivity toward Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Zebrafish (Danio rerio), Guinea Pig and Saccharomyces cerevisiae.

Quick Overview for PDE11A antibody (C-Term) (ABIN2789717)

Target: PDE11A (phosphodiesterase 11A (PDE11A))

Reactivity: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Zebrafish (Danio rerio), Guinea Pig, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE11A antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PDE11A Antibody

Binding Specificity: C-Term

Purpose: PDE11A Antibody - C-terminal region

Sequence: VTSEFFEQGD RERLELKLTP SAIFDRNRKD ELPRLQLEWI DSICMPLYQA

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 91%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against PDE11A. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP64064-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for PDE11A

Target: PDE11A (phosphodiesterase 11A (PDE11A))

Alternative Name: PDE11A

Background:

Background Information: The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia.

Gene Name: Phosphodiesterase 11A

Alternative Symbols: PPNAD2

Protein Name: Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A

Molecular Weight: 56kDa

Gene ID: 50940

NCBI Accession: NP_001070664

UniProt: Q9HCR9

Pathways: cAMP Metabolic Process