IL-19 antibody (C-Term)

Catalog No. ABIN2789719

This Rabbit Polyclonal antibody specifically detects IL-19 in WB. It exhibits reactivity toward Human, Rat, Mouse, Dog, Cow and Pig.

Quick Overview for IL-19 antibody (C-Term) (ABIN2789719)

Target: IL-19 (IL19) (Interleukin 19 (IL19))

Reactivity: Human, Rat, Mouse, Dog, Cow, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL-19 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-IL-19 Antibody

Binding Specificity: C-Term

Purpose: IL19 Antibody - C-terminal region

Sequence: KILRKISSIA NSFLYMQKTL RQCQEQRQCH CRQEATNATR VIHDNYDQLE

Predicted Reactivity: Cow: 93%, Dog: 79%, Human: 100%, Mouse: 85%, Pig: 93%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against IL19. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human IL19

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP64070-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for IL-19

Target: IL-19 (IL19) (Interleukin 19 (IL19))

Alternative Name: IL19

Background:

Background Information: The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described.

Gene Name: interleukin 19

Alternative Symbols: MDA1, NG.1, ZMDA1, IL-10C

Protein Name: Interleukin 19 EMBL CAH71814.1

Molecular Weight: 23kDa

Gene ID: 29949

NCBI Accession: NP_715639

UniProt: Q5VUT3