Deoxyguanosine Kinase antibody (C-Term)

Catalog No. ABIN2789830

Product Details anti-Deoxyguanosine Kinase Antibody

Target: Deoxyguanosine Kinase (DGUOK)

Binding Specificity: C-Term

Reactivity: Human, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Deoxyguanosine Kinase antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: EQLHGQHEAW LIHKTTKLHF EALMNIPVLV LDVNDDFSEE VTKQEDLMRE

Predicted Reactivity: Cow: 86%, Dog: 93%, Guinea Pig: 79%, Horse: 79%, Human: 100%, Pig: 86%, Rabbit: 86%, Rat: 85%

Characteristics: This is a rabbit polyclonal antibody against DGUOK. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human DGUOK

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 277 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Deoxyguanosine Kinase

Target: Deoxyguanosine Kinase (DGUOK)

Alternative Name: DGUOK (DGUOK Products)

Background: In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by two deoxyribonucleoside kinases, cytosolic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. The protein encoded by this gene is responsible for phosphorylation of purine deoxyribonucleosides in the mitochondrial matrix. In addition, this protein phosphorylates several purine deoxyribonucleoside analogs used in the treatment of lymphoproliferative disorders, and this phosphorylation is critical for the effectiveness of the analogs. Alternative splice variants encoding different protein isoforms have been described for this gene.
Alias Symbols: dGK
Protein Interaction Partner: UBC, PXN, LIG4, APP, DGUOK,
Protein Size: 277

Molecular Weight: 28 kDa

Gene ID: 1716

NCBI Accession: NM_080916, NP_550438

UniProt: Q16854

Pathways: Ribonucleoside Biosynthetic Process