KRT6A antibody (Middle Region)

Catalog No. ABIN2789833

The Rabbit Polyclonal anti-KRT6A antibody has been validated for WB. It is suitable to detect KRT6A in samples from Human, Mouse, Rat, Horse, Cow, Dog, Pig, Rabbit and Sheep.

Quick Overview for KRT6A antibody (Middle Region) (ABIN2789833)

Target: KRT6A (Keratin 6A (KRT6A))

Reactivity: Human, Mouse, Rat, Horse, Cow, Dog, Pig, Rabbit, Sheep

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KRT6A antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-KRT6A Antibody

Binding Specificity: Middle Region

Sequence: RGMQDLVEDF KNKYEDEINK RTAAENEFVT LKKDVDAAYM NKVELQAKAD

Predicted Reactivity: Cow: 100%, Dog: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Sheep: 93%

Characteristics: This is a rabbit polyclonal antibody against KRT6A. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 564 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for KRT6A

Target: KRT6A (Keratin 6A (KRT6A))

Alternative Name: KRT6A

Background: The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified, the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.
Alias Symbols: CK6A, CK6C, CK6D, K6A, K6C, K6D, KRT6C, KRT6D
Protein Interaction Partner: TRIM54, KRT40, TFIP11, HGS, KRT38, SGTA, KRT31, KRT15, KRT13, KIFC3, GOLGA2, TRIM23, LGR4, EED, KDM1A, PAN2, Iqcb1, Nphp4, Cep290, Nphp1, Invs, UBC, ITGA4, ALB, UBASH3B, SHC1, GRB2, EPS15, CRK, AP2M1, CBL, CUL1, COPS5, CUL2, CUL5, CCDC85B, TCHP, CCDC53, K
Protein Size: 564

Molecular Weight: 59 kDa

Gene ID: 3853

NCBI Accession: NM_005554, NP_005545

UniProt: P02538