DMGDH antibody (C-Term)

Catalog No. ABIN2789894

This Rabbit Polyclonal antibody specifically detects DMGDH in WB. It exhibits reactivity toward Human, Rat, Pig and Horse.

Quick Overview for DMGDH antibody (C-Term) (ABIN2789894)

Target: DMGDH (Dimethylglycine Dehydrogenase (DMGDH))

Reactivity: Human, Rat, Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DMGDH antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-DMGDH Antibody

Binding Specificity: C-Term

Purpose: DMGDH Antibody - C-terminal region

Sequence: YVPVQLSEVG QQVEVELLGK NYPAVIIQEP LVLTEPTRNR LQKKGGKDKT

Predicted Reactivity: Horse: 92%, Human: 100%, Pig: 100%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against DMGDH. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP64603-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for DMGDH

Target: DMGDH (Dimethylglycine Dehydrogenase (DMGDH))

Alternative Name: DMGDH

Background:

Background Information: This gene encodes an enzyme involved in the catabolism of choline, catalyzing the oxidative demethylation of dimethylglycine to form sarcosine. The enzyme is found as a monomer in the mitochondrial matrix, and uses flavin adenine dinucleotide and folate as cofactors. Mutation in this gene causes dimethylglycine dehydrogenase deficiency, characterized by a fishlike body odor, chronic muscle fatigue, and elevated levels of the muscle form of creatine kinase in serum.

Gene Name: Dimethylglycine dehydrogenase

Alternative Symbols: DMGDHD, ME2GLYDH

Protein Name: Dimethylglycine dehydrogenase, mitochondrial

Molecular Weight: 91kDa

Gene ID: 29958

NCBI Accession: NP_037523

UniProt: Q9UI17