DMGDH antibody (Middle Region)

Catalog No. ABIN2789895

Product Details anti-DMGDH Antibody

Target: DMGDH (Dimethylglycine Dehydrogenase (DMGDH))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Pig, Horse, Rabbit, Zebrafish (Danio rerio), Cow, Dog, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DMGDH antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: SELHDLRWIE EAAFRGGYDV EIQNITDEFG VLGVAGPYAR RVLQKLTSE

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 83%

Characteristics: This is a rabbit polyclonal antibody against Dmgdh. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of mouse DMGDH

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for DMGDH

Target: DMGDH (Dimethylglycine Dehydrogenase (DMGDH))

Alternative Name: Dmgdh (DMGDH Products)

Synonyms: MGC132281 antibody, DMGDHD antibody, ME2GLYDH antibody, Me2GlyDH antibody, 1200014D15Rik antibody, AI787269 antibody, dimethylglycine dehydrogenase antibody, dimethylglycine dehydrogenase L homeolog antibody, D-amino-acid oxidase antibody, Dimethylglycine dehydrogenase antibody, glycine cleavage system protein T antibody, dimethylglycine dehydrogenase precursor antibody, DMGDH antibody, dmgdh.L antibody, dmgdh antibody, SAR11_1253 antibody, EAMY_RS27375 antibody, EAMY_RS33570 antibody, VDBG_06516 antibody, Sinme_2570 antibody, HALXA_RS03495 antibody, Dmgdh antibody

Background: This gene encodes an enzyme involved in the catabolism of choline, catalyzing the oxidative demethylation of dimethylglycine to form sarcosine. The enzyme is found as a monomer in the mitochondrial matrix, and uses flavin adenine dinucleotide and folate as cofactors. Mutation in this gene causes dimethylglycine dehydrogenase deficiency, characterized by a fishlike body odor, chronic muscle fatigue, and elevated levels of the muscle form of creatine kinase in serum. Alternative splicing results in multiple transcript variants.
Alias Symbols: DMGDHD, ME2GLYDH
Protein Size: 869

Molecular Weight: 93 kDa

Gene ID: 29958

NCBI Accession: NM_013391, NP_037523

UniProt: Q9UI17