MMP25 antibody (Middle Region)

Catalog No. ABIN2789901

This Rabbit Polyclonal antibody specifically detects MMP25 in WB. It exhibits reactivity toward Human, Mouse, Rat, Dog, Guinea Pig, Horse and Rabbit.

Quick Overview for MMP25 antibody (Middle Region) (ABIN2789901)

Target: MMP25 (Matrix Metallopeptidase 25 (MMP25))

Reactivity: Human, Mouse, Rat, Dog, Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MMP25 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MMP25 Antibody

Binding Specificity: Middle Region

Sequence: FGHALGLGHS SAPNSIMRPF YQGPVGDPDK YRLSQDDRDG LQQLYGKAPQ

Predicted Reactivity: Dog: 82%, Guinea Pig: 86%, Horse: 86%, Human: 100%, Mouse: 79%, Rabbit: 100%, Rat: 92%

Characteristics: This is a rabbit polyclonal antibody against MMP25. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 562 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for MMP25

Target: MMP25 (Matrix Metallopeptidase 25 (MMP25))

Alternative Name: MMP25

Background: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25.
Alias Symbols: MMP20, MMP20A, MMPL1, MT-MMP6, MT6-MMP
Protein Interaction Partner: CLU, MMP2,
Protein Size: 562

Molecular Weight: 48 kDa

Gene ID: 64386

NCBI Accession: NM_022468, NP_071913

UniProt: Q9NPA2