PDE8B antibody (Middle Region)

Catalog No. ABIN2789902

The Rabbit Polyclonal anti-PDE8B antibody (ABIN2789902) specifically detects PDE8B in WB. The antibody is reactive with Human, Mouse, Horse, Cow, Dog, Pig, Guinea Pig, Rat and Zebrafish (Danio rerio) samples.

Quick Overview for PDE8B antibody (Middle Region) (ABIN2789902)

Target: PDE8B (phosphodiesterase 8B (PDE8B))

Reactivity: Human, Mouse, Horse, Cow, Dog, Pig, Guinea Pig, Rat, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE8B antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PDE8B Antibody

Binding Specificity: Middle Region

Purpose: PDE8B Antibody - middle region

Sequence: TELYSPQLGT KDEDPHTSDL VGGLMTDGLR RLSGNEYVFT KNVHQSHSHL

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against PDE8B. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP64625-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for PDE8B

Target: PDE8B (phosphodiesterase 8B (PDE8B))

Alternative Name: PDE8B

Background:

Background Information: The protein encoded by this gene is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP. The encoded protein, which does not hydrolyze cGMP, is resistant to several PDE inhibitors. Defects in this gene are a cause of autosomal dominant striatal degeneration (ADSD). Several transcript variants encoding different isoforms have been found for this gene.

Gene Name: Phosphodiesterase 8B

Alternative Symbols: ADSD, PPNAD3

Protein Name: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B

Molecular Weight: 87kDa

Gene ID: 8622

NCBI Accession: NP_001025022

UniProt: O95263

Pathways: Negative Regulation of Hormone Secretion, cAMP Metabolic Process