SUCLA2 antibody (C-Term)

Catalog No. ABIN2789919

This Rabbit Polyclonal antibody specifically detects SUCLA2 in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Horse, Pig, Dog, Guinea Pig and Rabbit.

Quick Overview for SUCLA2 antibody (C-Term) (ABIN2789919)

Target: SUCLA2 (Succinate-CoA Ligase, ADP-Forming, beta Subunit (SUCLA2))

Reactivity: Human, Mouse, Rat, Cow, Horse, Pig, Dog, Guinea Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SUCLA2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SUCLA2 Antibody

Binding Specificity: C-Term

Purpose: SUCLA2 Antibody - C-terminal region

Sequence: FDLQDWTQED ERDKDAAKAN LNYIGLDGNI GCLVNGAGLA MATMDIIKLH

Predicted Reactivity: Cow: 100%, Dog: 86%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 86%, Pig: 100%, Rabbit: 100%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against SUCLA2. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP64675-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for SUCLA2

Target: SUCLA2 (Succinate-CoA Ligase, ADP-Forming, beta Subunit (SUCLA2))

Alternative Name: SUCLA2

Background:

Targeted Subunit: beta, mitochondrial

Background Information: Succinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha subunit and a substrate-specific beta subunit. The protein encoded by this gene is an ATP-specific SCS beta subunit that dimerizes with the SCS alpha subunit to form SCS-A, an essential component of the tricarboxylic acid cycle. SCS-A hydrolyzes ATP to convert succinate to succinyl-CoA. Defects in this gene are a cause of myopathic mitochondrial DNA depletion syndrome. A pseudogene of this gene has been found on chromosome 6.

Gene Name: Succinate-CoA ligase, ADP-forming, beta subunit

Alternative Symbols: A-SCS, A-BETA, MTDPS5, LINC00444, SCS-betaA

Protein Name: Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial

Molecular Weight: 45kDa

Gene ID: 8803

NCBI Accession: NP_003841

UniProt: Q9P2R7