TXNRD3 antibody (Middle Region)

Catalog No. ABIN2789949

The Rabbit Polyclonal anti-TXNRD3 antibody is suitable to detect TXNRD3 in samples from Human, Mouse, Rabbit, Dog, Guinea Pig, Horse, Pig, Rat and Zebrafish (Danio rerio). It has been validated for WB.

Quick Overview for TXNRD3 antibody (Middle Region) (ABIN2789949)

Target: TXNRD3 (Thioredoxin Reductase 3 (TXNRD3))

Reactivity: Human, Mouse, Rabbit, Dog, Guinea Pig, Horse, Pig, Rat, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TXNRD3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TXNRD3 Antibody

Binding Specificity: Middle Region

Purpose: TXNRD3 Antibody - middle region

Sequence: NHISSLNWGY RLSLREKAVA YVNSYGEFVE HHKIKATNKK GQETYYTAAQ

Predicted Reactivity: Dog: 86%, Guinea Pig: 77%, Horse: 86%, Human: 100%, Mouse: 93%, Pig: 86%, Rabbit: 85%, Rat: 79%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against TXNRD3. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP64749-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for TXNRD3

Target: TXNRD3 (Thioredoxin Reductase 3 (TXNRD3))

Alternative Name: TXNRD3

Background:

Background Information: This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein catalyzes the reduction of thioredoxin, and is implicated in the defense against oxidative stress. It contains a selenocysteine (Sec) residue (which is essential for catalytic activity), encoded by a UGA codon, at the penultimate C-terminal position. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene Name: Thioredoxin reductase 3

Alternative Symbols: TGR, TR2, TRXR3, TR2IT1, TXNRD3NB, TXNRD3IT1, TXNRD3NT1

Protein Name: Thioredoxin reductase 3

Molecular Weight: 66kDa

Gene ID: 114112

NCBI Accession: NP_001166984

UniProt: Q86VQ6

Pathways: Cell RedoxHomeostasis