Plakophilin 4 antibody (N-Term)

Catalog No. ABIN2789970

This Rabbit Polyclonal antibody specifically detects Plakophilin 4 in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Pig, Rabbit, Dog, Guinea Pig and Horse.

Quick Overview for Plakophilin 4 antibody (N-Term) (ABIN2789970)

Target: Plakophilin 4 (PKP4)

Reactivity: Human, Mouse, Rat, Cow, Pig, Rabbit, Dog, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Plakophilin 4 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Plakophilin 4 Antibody

Binding Specificity: N-Term

Purpose: PKP4 Antibody - N-terminal region

Sequence: MPAPEQASLV EEGQPQTRQE AASTGPGMEP ETTATTILAS VKEQELQFQR

Predicted Reactivity: Cow: 100%, Dog: 93%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 86%, Pig: 100%, Rabbit: 93%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against PKP4. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP64810-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for Plakophilin 4

Target: Plakophilin 4 (PKP4)

Alternative Name: PKP4

Background:

Background Information: Armadillo-like proteins are characterized by a series of armadillo repeats, first defined in the Drosophila 'armadillo' gene product, that are typically 42 to 45 amino acids in length. These proteins can be divided into subfamilies based on their number of repeats, their overall sequence similarity, and the dispersion of the repeats throughout their sequences. Members of the p120(ctn)/plakophilin subfamily of Armadillo-like proteins, including CTNND1, CTNND2, PKP1, PKP2, PKP4, and ARVCF. PKP4 may be a component of desmosomal plaque and other adhesion plaques and is thought to be involved in regulating junctional plaque organization and cadherin function. Multiple transcript variants have been found for this gene, but the full-length nature of only two of them have been described so far.

Gene Name: Plakophilin 4

Alternative Symbols: p0071

Protein Name: Plakophilin-4

Molecular Weight: 127kDa

Gene ID: 8502

NCBI Accession: NP_001005476

UniProt: Q99569

Pathways: Cell-Cell Junction Organization