C8orf4 antibody (N-Term)

Catalog No. ABIN2790028

The Rabbit Polyclonal anti-C8orf4 antibody has been validated for WB. It is suitable to detect C8orf4 in samples from Human, Mouse, Rat, Guinea Pig, Cow, Dog, Horse and Rabbit.

Quick Overview for C8orf4 antibody (N-Term) (ABIN2790028)

Target: C8orf4 (Chromosome 8 Open Reading Frame 4 (C8orf4))

Reactivity: Human, Mouse, Rat, Guinea Pig, Cow, Dog, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C8orf4 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-C8orf4 Antibody

Binding Specificity: N-Term

Sequence: TASRKKAVGN IFENTDQESL ERLFRNSGDK KAEERAKIIF AIDQDVEEKT

Predicted Reactivity: Cow: 100%, Dog: 93%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 92%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against C8orf4. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human C8orf4

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 106 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for C8orf4

Target: C8orf4 (Chromosome 8 Open Reading Frame 4 (C8orf4))

Alternative Name: C8orf4

Background: This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies.
Alias Symbols: MGC22806, TC-1, TC1, hTC-1
Protein Interaction Partner: ELAVL1, UBC,
Protein Size: 106

Molecular Weight: 12 kDa

Gene ID: 56892

NCBI Accession: NM_020130, NP_064515

UniProt: Q9NR00