DEF6 antibody (C-Term)

Catalog No. ABIN2790082

This anti-DEF6 antibody is a Rabbit Polyclonal antibody detecting DEF6 in WB. Suitable for Human, Mouse, Rat, Dog, Pig, Cow, Guinea Pig, Horse and Rabbit.

Quick Overview for DEF6 antibody (C-Term) (ABIN2790082)

Target: DEF6 (Differentially Expressed in FDCP 6 Homolog (DEF6))

Reactivity: Human, Mouse, Rat, Dog, Pig, Cow, Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DEF6 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-DEF6 Antibody

Binding Specificity: C-Term

Sequence: QERYIERAQQ EKEELQQEMA QQSRSLQQAQ QQLEEVRQNR QRADEDVEAA

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 83%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 90%, Rabbit: 93%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against DEF6. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of human BRCC3

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for DEF6

Target: DEF6 (Differentially Expressed in FDCP 6 Homolog (DEF6))

Alternative Name: DEF6

Background: This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5.
Alias Symbols: C6.1A, BRCC36, CXorf53
Protein Size: 376

Molecular Weight: 41 kDa

Gene ID: 79184

NCBI Accession: NM_001018055, NP_001018065

UniProt: P46736