BRCA1-A Complex Subunit Abraxas 1 (ABRAXAS1) (C-Term) antibody

Catalog No. ABIN2790106

The Rabbit Polyclonal anti-BRCA1-A Complex Subunit Abraxas 1 antibody is suitable to detect BRCA1-A Complex Subunit Abraxas 1 in samples from Human, Rabbit, Pig, Horse, Dog and Cow. It has been validated for WB.

Quick Overview for BRCA1-A Complex Subunit Abraxas 1 (ABRAXAS1) (C-Term) antibody (ABIN2790106)

Target: BRCA1-A Complex Subunit Abraxas 1 (ABRAXAS1)

Reactivity: Human, Rabbit, Pig, Horse, Dog, Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB)

Product Details

Binding Specificity: C-Term

Purpose: ABRAXAS1 Antibody - C-terminal region

Sequence: DDRWQFKRSR LLDTQDKRSK ADTGSSNQDK ASKMSSPETD EEIEKMKGFG

Predicted Reactivity: Cow: 85%, Dog: 79%, Horse: 100%, Human: 100%, Pig: 79%, Rabbit: 100%

Characteristics: This is a rabbit polyclonal antibody against FAM175A. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP65319-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details

Target: BRCA1-A Complex Subunit Abraxas 1 (ABRAXAS1)

Alternative Name: ABRAXAS1

Background:

Targeted Subunit: Abraxas

Background Information: This gene encodes a protein that binds to the C-terminal repeats of breast cancer 1 (BRCA1) through a phospho-SXXF motif. The encoded protein recruits ubiquitin interaction motif containing 1 protein to BRCA1 protein and is required for DNA damage resistance, DNA repair, and cell cycle checkpoint control. Pseudogenes of this gene are found on chromosomes 3 and 8. Alternative splicing results in multiple transcript variants.

Gene Name: abraxas 1, BRCA1 A complex subunit

Alternative Symbols: ABRA1, CCDC98, FAM175A

Protein Name: BRCA1-A complex subunit Abraxas 1

Molecular Weight: 47kDa

Gene ID: 84142

NCBI Accession: NP_620775

UniProt: Q6UWZ7