ARPC1B antibody (Middle Region)

Catalog No. ABIN2790243

This Rabbit Polyclonal antibody specifically detects ARPC1B in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit and Zebrafish (Danio rerio).

Quick Overview for ARPC1B antibody (Middle Region) (ABIN2790243)

Target: ARPC1B (Actin Related Protein 2/3 Complex, Subunit 1B, 41kDa (ARPC1B))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ARPC1B antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ARPC1B Antibody

Binding Specificity: Middle Region

Sequence: KKPIRSTVLS LDWHPNNVLL AAGSCDFKCR IFSAYIKEVE ERPAPTPWGS

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against ARPC1B. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human ARPC1B

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 372 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ARPC1B

Target: ARPC1B (Actin Related Protein 2/3 Complex, Subunit 1B, 41kDa (ARPC1B))

Alternative Name: ARPC1B

Background: This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. This protein also has a role in centrosomal homeostasis by being an activator and substrate of the Aurora A kinase.
Alias Symbols: ARC41, p40-ARC, p41-ARC
Protein Interaction Partner: SUMO2, UBC, SUMO1, NEDD8, BTF3L4, C14orf142, IPO11, TPRKB, PDCD4, ANP32B, ARPC2, ACTR2, ACTR3, ARPC3, ARPC4, ARPC5, TOM1L1, ANP32A, VBP1, UBE3A, TPD52L2, TPD52, RPA2, RANGAP1, PRKACB, PPP2R5D, METTL1, HSF1, DR1, DHPS, CALU, CALR, AARS, SRPK2, PAN2, WASL,
Protein Size: 372

Molecular Weight: 41 kDa

Gene ID: 10095

NCBI Accession: NM_005720, NP_005711

UniProt: O15143

Pathways: RTK Signaling, Regulation of Actin Filament Polymerization