Importin 8 antibody (C-Term)

Catalog No. ABIN2790260

This Rabbit Polyclonal antibody specifically detects Importin 8 in WB. It exhibits reactivity toward Human, Rat, Dog, Horse and Guinea Pig.

Quick Overview for Importin 8 antibody (C-Term) (ABIN2790260)

Target: Importin 8 (IPO8)

Reactivity: Human, Rat, Dog, Horse, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Importin 8 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Importin 8 Antibody

Binding Specificity: C-Term

Purpose: IPO8 Antibody - C-terminal region

Sequence: PPAVDAVVGQ IVPSILFLFL GLKQVCATRQ LVNREDRSKA EKADMEENEE

Predicted Reactivity: Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against IPO8. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human IPO8

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP65771-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for Importin 8

Target: Importin 8 (IPO8)

Alternative Name: IPO8

Background:

Background Information: The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. This protein binds to the nuclear pore complex and, along with RanGTP and RANBP1, inhibits the GAP stimulation of the Ran GTPase. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene Name: Importin 8

Alternative Symbols: RANBP8

Protein Name: Importin-8

Molecular Weight: 96kDa

Gene ID: 10526

NCBI Accession: NP_001177924

UniProt: O15397