EIF2B3 antibody (Middle Region)

Catalog No. ABIN2790398

The Rabbit Polyclonal anti-EIF2B3 antibody is suitable to detect EIF2B3 in samples from Human, Mouse, Rat, Dog, Cow, Horse, Guinea Pig, Rabbit and Saccharomyces cerevisiae. It has been validated for WB.

Quick Overview for EIF2B3 antibody (Middle Region) (ABIN2790398)

Target: EIF2B3 (Eukaryotic Translation Initiation Factor 2B, Subunit 3 Gamma, 58kDa (EIF2B3))

Reactivity: Human, Mouse, Rat, Dog, Cow, Horse, Guinea Pig, Rabbit, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EIF2B3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-EIF2B3 Antibody

Binding Specificity: Middle Region

Sequence: ENGSITSIRS ELIPYLVRKQ FSSASSQQGQ EEKEEDLKKK ELKSLDIYSF

Predicted Reactivity: Cow: 100%, Dog: 93%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 86%, Rabbit: 93%, Rat: 93%, Yeast: 90%

Characteristics: This is a rabbit polyclonal antibody against EIF2B3. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human EIF2B3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 452 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for EIF2B3

Target: EIF2B3 (Eukaryotic Translation Initiation Factor 2B, Subunit 3 Gamma, 58kDa (EIF2B3))

Alternative Name: EIF2B3

Background: The protein encoded by this gene is one of the subunits of initiation factor eIF2B, which catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. It has also been found to function as a cofactor of hepatitis C virus internal ribosome entry site-mediated translation. Mutations in this gene have been associated with leukodystrophy with vanishing white matter. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: EIF-2B, EIF2Bgamma
Protein Interaction Partner: UBC, C14orf166, RTCB, DIMT1, NELFB, EDC4, IGF2BP3, G3BP1, EIF2B2, EIF3C, YBX3, RFC4, QARS, NMT1, HNRNPM, MRE11A, ILF2, HNRNPU, FLII, FKBP3, DHX9, DDX1, ABCF1, FBXO6, EGFR, EIF2B5, EIF2B4, NDUFB8, EIF2B3, GOLM1, EIF2S2, EIF2S1, STC2, EIF2B1,
Protein Size: 452

Molecular Weight: 50 kDa

Gene ID: 8891

NCBI Accession: NM_020365, NP_065098

UniProt: Q9NR50