DAND5 antibody (C-Term)

Catalog No. ABIN2790536

This Rabbit Polyclonal antibody specifically detects DAND5 in WB. It exhibits reactivity toward Human.

Quick Overview for DAND5 antibody (C-Term) (ABIN2790536)

Target: DAND5 (DAN Domain Family, Member 5 (DAND5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DAND5 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-DAND5 Antibody

Binding Specificity: C-Term

Purpose: DAND5 Antibody - C-terminal region

Sequence: YIPGSDPTPL VLCNSCMPAR KRWAPVVLWC LTGSSASRRR VKISTMLIEG

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against DAND5. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human DAND5

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP66787-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for DAND5

Target: DAND5 (DAN Domain Family, Member 5 (DAND5))

Alternative Name: DAND5

Background:

Background Information: This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to bind Nodal and to inhibit the Nodal signaling pathway which patterns left/right body asymmetry.

Alternative Symbols: SP1, CER2, COCO, CRL2, CERL2, DANTE, GREM3, CKTSF1B3

Protein Name: DAN domain family member 5

Molecular Weight: 21kDa

Gene ID: 199699

NCBI Accession: NP_689867

UniProt: Q8N907