IYD antibody (N-Term)

Catalog No. ABIN1544769

The Rabbit Polyclonal anti-IYD antibody (ABIN1544769) specifically detects IYD in WB. The antibody is reactive with Human, Rat, Cow, Dog and Rabbit samples.

Quick Overview for IYD antibody (N-Term) (ABIN1544769)

Target: IYD (Iodotyrosine Deiodinase (IYD))

Reactivity: Human, Rat, Cow, Dog, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IYD antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-IYD Antibody

Binding Specificity: N-Term

Purpose: IYD Antibody - N-terminal region

Sequence: NADRSMEKKK GEPRTRAEAR PWVDEDLKDS SDLHQAEEDA DEWQESEENV

Predicted Reactivity: Cow: 77%, Dog: 79%, Human: 100%, Rabbit: 79%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against IYD. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human IYD

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP66837-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for IYD

Target: IYD (Iodotyrosine Deiodinase (IYD))

Alternative Name: IYD

Background:

Background Information: This gene encodes an enzyme that catalyzes the oxidative NADPH-dependent deiodination of mono- and diiodotyrosine, which are the halogenated byproducts of thyroid hormone production. The N-terminus of the protein functions as a membrane anchor. Mutations in this gene cause congenital hypothyroidism due to dyshormonogenesis type 4, which is also referred to as deiodinase deficiency, or iodotyrosine dehalogenase deficiency, or thyroid hormonogenesis type 4.

Alternative Symbols: TDH4, IYD-1, DEHAL1, C6orf71

Protein Name: Iodotyrosine dehalogenase 1

Molecular Weight: 27kDa

Gene ID: 389434

NCBI Accession: NP_001158167

UniProt: Q6PHW0

Pathways: Thyroid Hormone Synthesis