MYSM1 antibody (C-Term)

Catalog No. ABIN2790657

This Rabbit Polyclonal antibody specifically detects MYSM1 in WB. It exhibits reactivity toward Human, Dog and Rabbit.

Quick Overview for MYSM1 antibody (C-Term) (ABIN2790657)

Target: MYSM1 (Myb-Like, SWIRM and MPN Domains 1 (MYSM1))

Reactivity: Human, Dog, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MYSM1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MYSM1 Antibody

Binding Specificity: C-Term

Sequence: CLQKLLECMR KTLSKVTNCF MAEEFLTEIE NLFLSNYKSN QENGVTEENC

Predicted Reactivity: Dog: 86%, Human: 100%, Rabbit: 77%

Characteristics: This is a rabbit polyclonal antibody against MYSM1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human MYSM1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 828 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for MYSM1

Target: MYSM1 (Myb-Like, SWIRM and MPN Domains 1 (MYSM1))

Alternative Name: MYSM1

Background: MYSM1 is a metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. It preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. MYSM1 acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation.
Alias Symbols: 2A-DUB, 2ADUB, DKFZp779J1554, DKFZp779J1721, KIAA1915, RP4-592A1.1
Protein Interaction Partner: UBC, DICER1, SUMO2, TUBB1, WDR77, STK38, PRMT5, KAT2B, HIST2H2AC, RBM10, KIF11, HSPA1A, HNRNPH1, EEF1A1,
Protein Size: 828

Molecular Weight: 91 kDa

Gene ID: 114803

NCBI Accession: NM_001085487, NP_001078956

UniProt: Q5VVJ2

Pathways: Chromatin Binding