AFG1-Like ATPase (AFG1L) (N-Term) antibody

Catalog No. ABIN2790804

This Rabbit Polyclonal antibody specifically detects AFG1-Like ATPase in WB. It exhibits reactivity toward Human, Cow, Dog, Guinea Pig, Horse and Rat.

Quick Overview for AFG1-Like ATPase (AFG1L) (N-Term) antibody (ABIN2790804)

Target: AFG1-Like ATPase (AFG1L)

Reactivity: Human, Cow, Dog, Guinea Pig, Horse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB)

Product Details

Binding Specificity: N-Term

Purpose: AFG1L Antibody - N-terminal region

Sequence: HGPLDHYDFL IKAHELKDDE HQRRVIQCLQ KLHEDLKGYN IEAEGLFSKL

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against LACE1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human LACE1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP67628-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details

Target: AFG1-Like ATPase (AFG1L)

Alternative Name: AFG1L

Background:

Background Information: This gene encodes a mitochondrial integral membrane protein that plays a role in mitochondrial protein homeostasis. The protein contains a P-loop motif and a five-domain structure that is conserved in fly, yeast, and bacteria. It functions to mediate the degradation of nuclear-encoded complex IV subunits. Two conserved estrogen receptor binding sites are located within 2.5 kb of this gene. Polymorphisms in this gene have been associated with bipolar disorder. Alternative splicing results in multiple transcript variants.

Gene Name: AFG1 like ATPase

Alternative Symbols: AFG1, LACE1, c222389

Protein Name: AFG1-like ATPase

Molecular Weight: 53kDa

Gene ID: 246269

NCBI Accession: NP_660358

UniProt: Q8WV93