YTHDF2 antibody (C-Term)

Catalog No. ABIN2790892

This Rabbit Polyclonal antibody specifically detects YTHDF2 in WB. It exhibits reactivity toward Human, Mouse, Rat, Rabbit, Cow, Dog and Horse.

Quick Overview for YTHDF2 antibody (C-Term) (ABIN2790892)

Target: YTHDF2 (YTH Domain Family, Member 2 (YTHDF2))

Reactivity: Human, Mouse, Rat, Rabbit, Cow, Dog, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This YTHDF2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-YTHDF2 Antibody

Binding Specificity: C-Term

Sequence: QEVPLEKAKQ VLKIIASYKH TTSIFDDFSH YEKRQEEEES VKKERQGRGK

Predicted Reactivity: Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against YTHDF2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human YTHDF2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 579 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for YTHDF2

Target: YTHDF2 (YTH Domain Family, Member 2 (YTHDF2))

Alternative Name: YTHDF2

Background: This gene encodes a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in plants. The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has a proline rich region which may be involved in signal transduction. An Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity. In addition, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosme 21 has been observed in patients with acute myeloid leukemia. This gene was initially mapped to chromosome 14, which was later turned out to be a pseudogene.
Alias Symbols: HGRG8, NY-REN-2
Protein Interaction Partner: UBC, RPA3, RPA2, RPA1, RNF2, BMI1, EIF3H, EIF3A, FBXO6, TARDBP, HIPK4, VCAM1, FN1, EPAS1, ESR1, APP, SMAD3, CAND1, CUL3, ELAVL1, POT1, MEPCE, HNRNPH1, HNRNPA1,
Protein Size: 579

Molecular Weight: 62 kDa

Gene ID: 51441

NCBI Accession: NM_016258, NP_057342

UniProt: Q9Y5A9