DENND1C antibody (C-Term)

Catalog No. ABIN2790995

This Rabbit Polyclonal antibody specifically detects DENND1C in WB. It exhibits reactivity toward Human.

Quick Overview for DENND1C antibody (C-Term) (ABIN2790995)

Target: DENND1C (DENN/MADD Domain Containing 1C (DENND1C))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DENND1C antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-DENND1C Antibody

Binding Specificity: C-Term

Purpose: DENND1C Antibody - C-terminal region

Sequence: PSSLEDPRAR PPKALLAERA HLQPREEPGA LNSPATPTSN CQKSQPSSRP

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against DENND1C. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human DENND1C

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP68265-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for DENND1C

Target: DENND1C (DENN/MADD Domain Containing 1C (DENND1C))

Alternative Name: DENND1C

Background:

Background Information: Clathrin-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1C, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 and bind to clathrin and clathrin adaptor protein-2. Thus, connecdenns link RAB35 activation with the clathrin machinery.

Alternative Symbols: FAM31C

Protein Name: DENN domain-containing protein 1C

Molecular Weight: 87kDa

Gene ID: 79958

NCBI Accession: NP_079174

UniProt: Q8IV53