KNSTRN antibody (Middle Region)

Catalog No. ABIN2791244

The Rabbit Polyclonal anti-KNSTRN antibody has been validated for WB. It is suitable to detect KNSTRN in samples from Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit and Saccharomyces cerevisiae.

Quick Overview for KNSTRN antibody (Middle Region) (ABIN2791244)

Target: KNSTRN (Kinetochore-Localized Astrin/SPAG5 Binding Protein (KNSTRN))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KNSTRN antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-KNSTRN Antibody

Binding Specificity: Middle Region

Sequence: TDTATRRNVR KGYKPLSKQK SEEELKDKNQ LLEAVNKQLH QKLTETQGEL

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 85%, Rabbit: 100%, Rat: 79%, Yeast: 82%

Characteristics: This is a rabbit polyclonal antibody against C15orf23. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human C15orf23

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 316 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for KNSTRN

Target: KNSTRN (Kinetochore-Localized Astrin/SPAG5 Binding Protein (KNSTRN))

Alternative Name: C15orf23

Background: C15orf23 is an essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase. It promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments.
Alias Symbols: SKAP, TRAF4AF1, C15orf23
Protein Interaction Partner: UBC, CLU, CHMP1B, MAPK6, Cep152, Cep55, Dynll1, Mad2l1, Spag5, Knstrn, Plk1, MPHOSPH6, MPP6,
Protein Size: 316

Molecular Weight: 35 kDa

Gene ID: 90417

NCBI Accession: NM_033286, NP_150628

UniProt: Q9Y448

Pathways: M Phase