KNSTRN antibody (N-Term)

Catalog No. ABIN2791245

The Rabbit Polyclonal anti-KNSTRN antibody (ABIN2791245) specifically detects KNSTRN in WB. The antibody is reactive with Human samples.

Quick Overview for KNSTRN antibody (N-Term) (ABIN2791245)

Target: KNSTRN (Kinetochore-Localized Astrin/SPAG5 Binding Protein (KNSTRN))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KNSTRN antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-KNSTRN Antibody

Binding Specificity: N-Term

Purpose: C15orf23 Antibody - N-terminal region

Sequence: YRKFLFETQA ADLAGGTTVA AGNLLNESEK DCGQDRRAPG VQPCRLVTMT

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against C15orf23. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human C15orf23

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP69086-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for KNSTRN

Target: KNSTRN (Kinetochore-Localized Astrin/SPAG5 Binding Protein (KNSTRN))

Alternative Name: C15orf23

Background:

Background Information: C15orf23 is an essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase. It promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments.

Alternative Symbols: SKAP, HSD11, C15orf23, TRAF4AF1

Protein Name: Small kinetochore-associated protein

Molecular Weight: 35kDa

Gene ID: 90417

NCBI Accession: NP_150628

UniProt: Q9Y448

Pathways: M Phase