PLD6 antibody (C-Term)

Catalog No. ABIN2791346

The Rabbit Polyclonal anti-PLD6 antibody (ABIN2791346) specifically detects PLD6 in WB. The antibody is reactive with Human samples.

Quick Overview for PLD6 antibody (C-Term) (ABIN2791346)

Target: PLD6 (Phospholipase D Family, Member 6 (PLD6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLD6 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PLD6 Antibody

Binding Specificity: C-Term

Purpose: PLD6 Antibody - C-terminal region

Sequence: ITEDDEYVRL FLEEFERIWE QFNPTKYTFF PPKKSHGSCA PPVSRAGGRL

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against PLD6. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human PLD6

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP69458-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for PLD6

Target: PLD6 (Phospholipase D Family, Member 6 (PLD6))

Alternative Name: PLD6

Background:

Background Information: PLD6 is a cardiolipin hydrolase present at the mitochondrial outer membrane required both for mitochondrial fusion and piRNA metabolic process. PLD6 acts by catalyzing the hydrolysis of cardiolipin (diphosphatidylglycerol) to form phosphatidate (phosphatidic acid or PA) at the mitochondrial outer membrane surface, promoting mitochondrial fusion. The production of phosphatidate also regulates the piRNA metabolic process by promoting recruitment and/or activation of components of the meiotic nuage, also named P granule, a critical step for primary biogenesis of piRNAs. It is required during spermatogenesis to repress transposable elements and prevent their mobilization via its role in the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons.

Alternative Symbols: ZUC

Protein Name: Mitochondrial cardiolipin hydrolase

Molecular Weight: 28kDa

Gene ID: 201164

NCBI Accession: NP_849158

UniProt: Q8N2A8

Pathways: Ribonucleoprotein Complex Subunit Organization