MVB12B antibody (C-Term)

Catalog No. ABIN2446370

The Rabbit Polyclonal anti-MVB12B antibody is suitable to detect MVB12B in samples from Human, Mouse, Rat, Guinea Pig, Cow, Dog, Horse and Rabbit. It has been validated for WB.

Quick Overview for MVB12B antibody (C-Term) (ABIN2446370)

Target: MVB12B (Multivesicular Body Subunit 12B (MVB12B))

Reactivity: Human, Mouse, Rat, Guinea Pig, Cow, Dog, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MVB12B antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MVB12B Antibody

Binding Specificity: C-Term

Sequence: HISLTLPATF RGRNSTRTDY EYQHSNLYAI SAMDGVPFMI SEKFSCVPES

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 85%, Rabbit: 93%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against MVB12B. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human MVB12B

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for MVB12B

Target: MVB12B (Multivesicular Body Subunit 12B (MVB12B))

Alternative Name: MVB12B

Background: The protein encoded by this gene is a component of the ESCRT-I complex, a heterotetramer, which mediates the sorting of ubiquitinated cargo protein from the plasma membrane to the endosomal vesicle. ESCRT-I complex plays an essential role in HIV budding and endosomal protein sorting. Depletion and overexpression of this and related protein (MVB12A) inhibit HIV-1 infectivity and induce unusual viral assembly defects, indicating a role for MVB12 subunits in regulating ESCRT-mediated virus budding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: C9orf28, MVB12B
Protein Interaction Partner: LNX1, gag, UBC, VPS37A, MVB12A, TSG101,
Protein Size: 319

Molecular Weight: 35 kDa

Gene ID: 89853

NCBI Accession: NM_033446, NP_258257

UniProt: Q9H7P6