NSMCE4A antibody (C-Term)

Catalog No. ABIN2791705

The Rabbit Polyclonal anti-NSMCE4A antibody is suitable to detect NSMCE4A in samples from Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit and Zebrafish (Danio rerio). It has been validated for WB and IF.

Quick Overview for NSMCE4A antibody (C-Term) (ABIN2791705)

Target: NSMCE4A (Non-SMC Element 4 Homolog A (NSMCE4A))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NSMCE4A antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-NSMCE4A Antibody

Binding Specificity: C-Term

Purpose: NSMCE4A Antibody - C-terminal region

Sequence: PVIQEERAMP AQLRRMEESH QEATEKEVER ILGLLQTYFR EDPDTPMSFF

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against NSMCE4A. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human NSMCE4A

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP70963-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for NSMCE4A

Target: NSMCE4A (Non-SMC Element 4 Homolog A (NSMCE4A))

Alternative Name: NSMCE4A

Background:

Background Information: NSMCE4A is a component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). It is involved in positive regulation of response to DNA damage stimulus.

Alternative Symbols: NS4EA, NSE4A, C10orf86

Protein Name: Non-structural maintenance of chromosomes element 4 homolog A

Molecular Weight: 44kDa

Gene ID: 54780

NCBI Accession: NP_060085

UniProt: Q9NXX6

Pathways: Positive Regulation of Response to DNA Damage Stimulus