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PDZD3 antibody (N-Term)

This anti-PDZD3 antibody is a Rabbit Polyclonal antibody detecting PDZD3 in WB. Suitable for Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit and Guinea Pig.
Catalog No. ABIN2791849

Quick Overview for PDZD3 antibody (N-Term) (ABIN2791849)

Target

See all PDZD3 Antibodies
PDZD3 (PDZ Domain Containing 3 (PDZD3))

Reactivity

Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit, Guinea Pig

Host

  • 21
  • 5
Rabbit

Clonality

  • 23
  • 3
Polyclonal

Conjugate

  • 17
  • 3
  • 2
  • 2
  • 1
  • 1
This PDZD3 antibody is un-conjugated

Application

  • 21
  • 17
  • 3
  • 1
Western Blotting (WB)
  • Binding Specificity

    • 7
    • 7
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term

    Sequence

    PDPWSLERPR FCLLSKEEGK SFGFHLQQEL GRAGHVVCRV DPGTSAQRQG

    Predicted Reactivity

    Cow: 79%, Dog: 93%, Guinea Pig: 93%, Horse: 79%, Human: 100%, Mouse: 86%, Pig: 100%, Rabbit: 86%, Rat: 93%

    Characteristics

    This is a rabbit polyclonal antibody against PDZD3. It was validated on Western Blot.

    Purification

    Affinity Purified

    Immunogen

    The immunogen is a synthetic peptide directed towards the N-terminal region of Human PDZD3
  • Application Notes

    Optimal working dilution should be determined by the investigator.

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 mg/mL

    Buffer

    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handling Advice

    Avoid repeat freeze-thaw cycles.

    Storage

    -20 °C

    Storage Comment

    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target

    PDZD3 (PDZ Domain Containing 3 (PDZD3))

    Alternative Name

    PDZD3

    Background

    Guanylyl cyclase C (GCC, or GUCY2C, MIM 601330) produces cGMP following the binding of either endogenous ligands or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR, MIM 602421), followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein that associates with GCC and regulates the amount of cGMP produced following receptor stimulation.
    Protein Interaction Partner: SPRYD7, ASAP3, SLC41A3, CACNA1S, PTGIR, SLC22A4, SLCO1A2, SLC15A2, SLCO1C1, GUCY2C, SLCO3A1, SLC22A9, SLC22A3, SLC22A5, CFTR, ABCC2, SLC15A1,
    Protein Size: 386

    Molecular Weight

    42 kDa

    Gene ID

    79849
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