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VHLL antibody (N-Term)

VHLL Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2791981
  • Target See all VHLL Antibodies
    VHLL (Von Hippel-Lindau Tumor Suppressor-Like (VHLL))
    Binding Specificity
    • 6
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    Human
    Host
    • 6
    • 3
    Rabbit
    Clonality
    • 7
    • 2
    Polyclonal
    Conjugate
    • 5
    • 2
    • 1
    • 1
    This VHLL antibody is un-conjugated
    Application
    • 6
    • 3
    • 1
    Western Blotting (WB)
    Sequence
    PWRAGNGVGL EAQAGTQEAG PEEYCQEELG AEEEMAARAA WPVLRSVNSR
    Predicted Reactivity
    Human: 100%
    Characteristics
    This is a rabbit polyclonal antibody against VHLL. It was validated on Western Blot.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N-terminal region of Human VHLL
    Top Product
    Discover our top product VHLL Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeat freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    VHLL (Von Hippel-Lindau Tumor Suppressor-Like (VHLL))
    Alternative Name
    VHLL (VHLL Products)
    Synonyms
    VHLP antibody, VLP antibody, VHL like antibody, VHLL antibody
    Background
    Von Hippel-Lindau (VHL) tumor suppressor protein is a component of an E3 ubiquitin ligase complex that selectively ubiquitinates the alpha subunit of the hypoxia-inducible factor (HIF) transcription factor for proteasome-mediated degradation. Inactivation of VHL causes VHL disease and sporadic kidney cancer. This gene encodes a VHL homolog that lacks one of two key domains necessary for VHL function. This gene may contribute to the regulation of oxygen homeostasis and neovascularization during placenta development. This gene is intronless, and can also be interpreted as a retrotransposed pseudogene of the VHL locus located on chromosome 3. However, the protein is represented in this RefSeq due to evidence in PMID:14757845 that strongly suggests it is translated. The same publication also indicates that this protein binds HIF alpha but fails to recruit the E3 ubiquitin ligase complex, and it therefore functions as a dominant-negative VHL protein and a protector of HIF alpha.
    Alias Symbols: VHLP, VLP
    Protein Interaction Partner: RBPMS, DAZAP2, HIF1A,
    Protein Size: 139
    Molecular Weight
    15 kDa
    Gene ID
    391104
    NCBI Accession
    NM_001004319, NP_001004319
    UniProt
    Q6RSH7
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