BCR antibody (N-Term)

Catalog No. ABIN2792051

The Rabbit Polyclonal anti-BCR antibody is suitable to detect BCR in samples from Human, Mouse, Rat, Dog, Zebrafish (Danio rerio), Horse, Rabbit, Guinea Pig and Cow. It has been validated for WB.

Quick Overview for BCR antibody (N-Term) (ABIN2792051)

Target: BCR (Breakpoint Cluster Region (BCR))

Reactivity: Human, Mouse, Rat, Dog, Zebrafish (Danio rerio), Horse, Rabbit, Guinea Pig, Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BCR antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-BCR Antibody

Binding Specificity: N-Term

Purpose: BCR Antibody - N-terminal region

Sequence: EDFSSGQSSR VSPSPTTYRM FRDKSRSPSQ NSQQSFDSSS PPTPQCHKRH

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 86%

Characteristics: This is a rabbit polyclonal antibody against BCR-ABL1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of human BCR

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP72510-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for BCR

Target: BCR (Breakpoint Cluster Region (BCR))

Alternative Name: BCR

Background:

Background Information: A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.

Gene Name: breakpoint cluster region

Alternative Symbols: ALL, CML, PHL, BCR1, D22S11, D22S662

Protein Name: breakpoint cluster region protein

Molecular Weight: 34kDa

Gene ID: 613

NCBI Accession: NP_004318

UniProt: P11274

Pathways: Regulation of Leukocyte Mediated Immunity, Platelet-derived growth Factor Receptor Signaling