DSCR3 antibody (Middle Region)

Catalog No. ABIN2792078

This Rabbit Polyclonal antibody specifically detects DSCR3 in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse and Rabbit.

Quick Overview for DSCR3 antibody (Middle Region) (ABIN2792078)

Target: DSCR3 (Down Syndrome Critical Region Gene 3 (DSCR3))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DSCR3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-DSCR3 Antibody

Binding Specificity: Middle Region

Purpose: VPS26C Antibody - middle region

Sequence: SAPQKGKFTP SPVDFTITPE TLQNVKERAL LPKFLLRGHL NSTNCVITQP

Predicted Reactivity: Cow: 86%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 86%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against DSCR3. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human DSCR3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP73191-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for DSCR3

Target: DSCR3 (Down Syndrome Critical Region Gene 3 (DSCR3))

Alternative Name: VPS26C

Background:

Background Information: The region of chromosome 21 between genes CBR and ERG (CBR-ERG region), which spans 2.5 Mb on 21q22.2, has been defined by analysis of patients with partial trisomy 21. It contributes significantly to the pathogenesis of many characteristics of Down syndrome, including morphological features, hypotonia, and cognitive disability. The DSCR3 (Down syndrome critical region gene 3) gene is found in this region and is predictated to contain eight exons. DSCR3 is expressed in most tissues examined.

Gene Name: VPS26 endosomal protein sorting factor C

Alternative Symbols: DCRA, DSCR3, DSCRA

Protein Name: Down syndrome critical region protein 3

Molecular Weight: 33kDa

Gene ID: 10311

NCBI Accession: XP_011527725

UniProt: O14972