BIRC7 antibody (Middle Region)

Catalog No. ABIN2792130

The Rabbit Polyclonal anti-BIRC7 antibody is suitable to detect BIRC7 in samples from Human, Cow, Dog and Rabbit. It has been validated for WB.

Quick Overview for BIRC7 antibody (Middle Region) (ABIN2792130)

Target: BIRC7 (Baculoviral IAP Repeat-Containing 7 (BIRC7))

Reactivity: Human, Cow, Dog, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BIRC7 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-BIRC7 Antibody

Binding Specificity: Middle Region

Purpose: BIRC7 Antibody - middle region

Sequence: EERTCKVCLD RAVSIVFVPC GHLVCAECAP GLQLCPICRA PVRSRVRTFL

Predicted Reactivity: Cow: 85%, Dog: 84%, Human: 100%, Rabbit: 92%

Characteristics: This is a rabbit polyclonal antibody against BIRC7. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human BIRC7

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for BIRC7

Target: BIRC7 (Baculoviral IAP Repeat-Containing 7 (BIRC7))

Alternative Name: BIRC7

Background:

Background Information: BIRC7 protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits caspase-3 and proteolytic activation of pro-caspase-9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis.The protein encoded by this gene is a member of the family of inhibitor of apoptosis proteins (IAP) and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Two transcript variants encoding different isoforms have been found for this gene. The two isoforms have different antiapoptotic properties, with isoform alpha protecting cells from apoptosis induced by staurosporine and isoform b protecting cells from apoptosis induced by etoposide.

Gene Name: Baculoviral IAP repeat containing 7

Alternative Symbols: KIAP, LIVIN, MLIAP, RNF50, ML-IAP

Protein Name: Baculoviral IAP repeat-containing protein 7

Molecular Weight: 33kDa

Gene ID: 79444

NCBI Accession: NP_647478

UniProt: Q96CA5