c-FOS antibody (N-Term)

Catalog No. ABIN2792182

The Rabbit Polyclonal anti-c-FOS antibody (ABIN2792182) specifically detects c-FOS in WB and IHC. The antibody is reactive with Human, Mouse, Rat, Cow, Pig, Dog and Sheep samples.

Quick Overview for c-FOS antibody (N-Term) (ABIN2792182)

Target: c-FOS (c-Fos) (c-Fos)

Reactivity: Human, Mouse, Rat, Cow, Pig, Dog, Sheep

Host: Rabbit

Clonality: Polyclonal

Conjugate: This c-FOS antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-c-FOS Antibody

Binding Specificity: N-Term

Purpose: FOS Antibody - N-terminal region

Sequence: MFSGFNADYE ASSSRCSSAS PAGDSLSYYH SPADSFSSMG SPVNAQDFCT

Predicted Reactivity: Cow: 100%, Dog: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%, Sheep: 100%

Characteristics: This is a rabbit polyclonal antibody against FOS. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human FOS

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for c-FOS

Target: c-FOS (c-Fos) (c-Fos)

Alternative Name: FOS

Background:

Background Information: The Fos family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. The family members are leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death.The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: FBJ murine osteosarcoma viral oncogene homolog

Alternative Symbols: p55, AP-1, C-FOS

Protein Name: Proto-oncogene c-Fos

Molecular Weight: 41kDa

Gene ID: 2353

NCBI Accession: NP_005243

UniProt: P01100

Pathways: S100 Proteins