Caveolin 3 antibody (N-Term)

Catalog No. ABIN2792221

This Rabbit Polyclonal antibody specifically detects Caveolin 3 in WB and IHC. It exhibits reactivity toward Human, Mouse, Rat, Pig and Cow.

Quick Overview for Caveolin 3 antibody (N-Term) (ABIN2792221)

Target: Caveolin 3 (CAV3)

Reactivity: Human, Mouse, Rat, Pig, Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Caveolin 3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-Caveolin 3 Antibody

Binding Specificity: N-Term

Sequence: MMAEEHTDLE AQIVKDIHCK EIDLVNRDPK NINEDIVKVD FEDVIAEPVG

Predicted Reactivity: Cow: 100%, Human: 100%, Mouse: 84%, Pig: 92%, Rat: 84%

Characteristics: This is a rabbit polyclonal antibody against CAV3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CAV3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 151 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Caveolin 3

Target: Caveolin 3 (CAV3)

Alternative Name: CAV3

Background: CAV3 is a caveolin family member, which functions as a component of the caveolae plasma membranes found in most cell types. Caveolin proteins are proposed to be scaffolding proteins for organizing and concentrating certain caveolin-interacting molecules. Mutations identified in this gene lead to interference with protein oligomerization or intra-cellular routing, disrupting caveolae formation and resulting in Limb-Girdle muscular dystrophy type-1C (LGMD-1C), hyperCKemia or rippling muscle disease (RMD). Alternative splicing has been identified for this locus, with inclusion or exclusion of a differentially spliced intron. In addition, transcripts utilize multiple polyA sites and contain two potential translation initiation sites.
Alias Symbols: LQT9, VIP21, LGMD1C, VIP-21
Protein Interaction Partner: KCNMA1, PTGES3, SCN5A, PCBP1, NEDD4L, KCNH2, SUMO2, SUMO3, ADRB2, JPH2, SLC22A11, DYSF, PFKM, SLC8A1, NOS1, INSR, GNAS, EGFR, DAG1, PDGFRB, PDGFRA,
Protein Size: 151

Molecular Weight: 17 kDa

Gene ID: 859

NCBI Accession: NM_001234, NP_001225

UniProt: P56539

Pathways: Carbohydrate Homeostasis, Regulation of Muscle Cell Differentiation, Regulation of Cell Size, Skeletal Muscle Fiber Development, Negative Regulation of Transporter Activity