DOK2 antibody (C-Term)

Catalog No. ABIN2792223

The Rabbit Polyclonal anti-DOK2 antibody (ABIN2792223) specifically detects DOK2 in WB. The antibody is reactive with Human, Mouse, Rat, Cow, Dog, Pig and Horse samples.

Quick Overview for DOK2 antibody (C-Term) (ABIN2792223)

Target: DOK2

Reactivity: Human, Mouse, Rat, Cow, Dog, Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DOK2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-DOK2 Antibody

Binding Specificity: C-Term

Purpose: DOK2 Antibody - C-terminal region

Sequence: QEPRGEAWRR QATRDRDPAG LQHVQPAGQD FSASGWQPGT EYDNVVLKKG

Predicted Reactivity: Cow: 100%, Dog: 90%, Horse: 90%, Human: 100%, Mouse: 90%, Pig: 100%, Rat: 90%

Characteristics: This is a rabbit polyclonal antibody against DOK2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human DOK2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for DOK2

Target: DOK2

Alternative Name: DOK2

Background:

Background Information: DOK2 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210 (bcr/abl), a chimeric protein whose presence is associated with CML. DOK2 binds p120 (RasGAP) from CML cells.The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells.

Gene Name: Docking protein 2, 56 kDa

Alternative Symbols: p56DOK, p56dok-2

Protein Name: Docking protein 2

Molecular Weight: 45kDa

Gene ID: 9046

NCBI Accession: NP_003965

UniProt: O60496