PDCD4 antibody (N-Term)

Catalog No. ABIN2792230

There are 2+ publications for this product available. The Rabbit Polyclonal anti-PDCD4 antibody is suitable to detect PDCD4 in samples from Human, Mouse, Rat, Cow, Dog, Rabbit, Goat and Guinea Pig. It has been validated for WB.

Quick Overview for PDCD4 antibody (N-Term) (ABIN2792230)

Target: PDCD4 (Programmed Cell Death 4 (PDCD4))

Reactivity: Human, Mouse, Rat, Cow, Dog, Rabbit, Goat, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDCD4 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PDCD4 Antibody

Binding Specificity: N-Term

Purpose: PDCD4 Antibody - N-terminal region

Sequence: MTKYPDNLSD SLFSGDEENA GTEEIKNEIN GNWISASSIN EARINAKAKR

Predicted Reactivity: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against PDCD4. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PDCD4

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-PDCD4 antibody (ABIN2792230)

Pan, Luo, Chegini: "microRNA 21: response to hormonal therapies and regulatory function in leiomyoma, transformed leiomyoma and leiomyosarcoma cells." in: Molecular human reproduction, Vol. 16, Issue 3, pp. 215-27, (2010) (PubMed).

Folini, Gandellini, Longoni, Profumo, Callari, Pennati, Colecchia, Supino, Veneroni, Salvioni, Valdagni, Daidone, Zaffaroni: "miR-21: an oncomir on strike in prostate cancer." in: Molecular cancer, Vol. 9, pp. 12, (2010) (PubMed).

Target Details for PDCD4

Target: PDCD4 (Programmed Cell Death 4 (PDCD4))

Alternative Name: PDCD4

Background:

Background Information: PDCD4 is a protein localized to the nucleus in proliferating cells. Expression of its gene is modulated by cytokines in natural killer and T cells. PDCD4 is thought to play a role in apoptosis but the specific role has not yet been determined.This gene encodes a protein localized to the nucleus in proliferating cells. Expression of this gene is modulated by cytokines in natural killer and T cells. The gene product is thought to play a role in apoptosis but the specific role has not yet been determined. Two transcripts encoding different isoforms have been identified.

Gene Name: Programmed cell death 4 (neoplastic transformation inhibitor)

Alternative Symbols: H731

Protein Name: Programmed cell death protein 4

Molecular Weight: 50kDa

Gene ID: 27250

NCBI Accession: NP_663314

UniProt: Q53EL6