DEK antibody (N-Term)

Catalog No. ABIN2792543

There is 1 publication for this product available. The Rabbit Polyclonal anti-DEK antibody is suitable to detect DEK in samples from Human, Rat, Cow, Rabbit, Guinea Pig and Horse. It has been validated for WB.

Quick Overview for DEK antibody (N-Term) (ABIN2792543)

Target: DEK (DEK Oncogene (DEK))

Reactivity: Human, Rat, Cow, Rabbit, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DEK antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-DEK Antibody

Binding Specificity: N-Term

Purpose: DEK Antibody - N-terminal region

Sequence: AAEGEGTPTQ PASEKEPEMP GPREESEEEE DEDDEEEEEE EKEKSLIVEG

Cross-Reactivity: Cow (Bovine), Human, Rat (Rattus)

Predicted Reactivity: Cow: 78%, Guinea Pig: 92%, Horse: 92%, Human: 100%, Rabbit: 85%, Rat: 85%

Characteristics: This is a rabbit polyclonal antibody against DEK. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human DEK

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-DEK antibody (ABIN2792543)

Wang, Eckert, Zomorrodi, Xin, Pan, Shearer, Weisz, Maranus, Clawson: "Down-regulation of HtrA1 activates the epithelial-mesenchymal transition and ATM DNA damage response pathways." in: PLoS ONE, Vol. 7, Issue 6, pp. e39446, (2012) (PubMed).

Target Details for DEK

Target: DEK (DEK Oncogene (DEK))

Alternative Name: DEK

Background:

Background Information: DEK was first identified in a fusion with the CAN nucleoporin protein in a specific subtype of acute myelogenous leukemia. DEK has also been shown to be an autoantigen in patients with pauciarticular onset juvenile rheumatoid arthritis. Further, the last 65 amino acids of DEK can partially reverse the mutation-prone phenotype of cells from patients with ataxia-telangiectasia

Gene Name: DEK oncogene

Alternative Symbols: D6S231E

Protein Name: Protein DEK

Molecular Weight: 43kDa

Gene ID: 7913

NCBI Accession: NP_003463

UniProt: P35659