RORA antibody (N-Term)

Catalog No. ABIN2792585

The Rabbit Polyclonal anti-RORA antibody is suitable to detect RORA in samples from Human and Cow. It has been validated for WB.

Quick Overview for RORA antibody (N-Term) (ABIN2792585)

Target: RORA (RAR-Related Orphan Receptor A (RORA))

Reactivity: Human, Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RORA antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-RORA Antibody

Binding Specificity: N-Term

Purpose: RORA Antibody - N-terminal region

Sequence: ARKSEPPAPV RRQSYSSTSR GISVTKKTHT SQIEIIPCKI CGDKSSGIHY

Cross-Reactivity: Human

Predicted Reactivity: Cow: 100%, Human: 100%

Characteristics: This is a rabbit polyclonal antibody against RORA. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human RORA

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for RORA

Target: RORA (RAR-Related Orphan Receptor A (RORA))

Alternative Name: RORA

Background:

Background Information: RORA is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Four transcript variants encoding different isoforms have been described for this gene.The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Four transcript variants encoding different isoforms have been described for this gene.

Gene Name: RAR-related orphan receptor A

Alternative Symbols: ROR1, ROR2, ROR3, RZRA, NR1F1, IDDECA, RZR-ALPHA

Protein Name: Retinoid-related orphan receptor alpha EMBL BAH02285.1

Molecular Weight: 59kDa

Gene ID: 6095

NCBI Accession: NP_599023

UniProt: B6ZGS4

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha