EGR2 antibody (C-Term)

Catalog No. ABIN2792631

There are 3+ publications for this product available. The Rabbit Polyclonal anti-EGR2 antibody is suitable to detect EGR2 in samples from Human, Mouse, Rat, Horse, Pig, Cow, Rabbit and Dog. It has been validated for WB, IHC (p) and IHC (fro).

Quick Overview for EGR2 antibody (C-Term) (ABIN2792631)

Target: EGR2 (Early Growth Response 2 (EGR2))

Reactivity: Human, Mouse, Rat, Horse, Pig, Cow, Rabbit, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EGR2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-EGR2 Antibody

Binding Specificity: C-Term

Purpose: EGR2 Antibody - C-terminal region

Sequence: PFACDYCGRK FARSDERKRH TKIHLRQKER KSSAPSASVP APSTASCSGG

Cross-Reactivity: Dog (Canine), Human, Mouse (Murine), Pig (Porcine), Rat (Rattus)

Predicted Reactivity: Cow: 100%, Dog: 92%, Horse: 85%, Human: 100%, Mouse: 100%, Pig: 92%, Rabbit: 92%, Rat: 92%

Characteristics: This is a rabbit polyclonal antibody against EGR2. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human EGR2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-EGR2 antibody (ABIN2792631)

Damm, Mylonas, Cosson, Yoshida, Della Valle, Mouly, Diop, Scourzic, Shiraishi, Chiba, Tanaka, Miyano, Kikushige, Davi, Lambert, Gautheret, Merle-Béral, Sutton, Dessen, Solary, Akashi, Vainchenker et al.: "Acquired initiating mutations in early hematopoietic cells of CLL patients. ..." in: Cancer discovery, Vol. 4, Issue 9, pp. 1088-101, (2014) (PubMed).

Lagrange, Martin, Droin, Aucagne, Paggetti, Largeot, Itzykson, Solary, Delva, Bastie: "A role for miR-142-3p in colony-stimulating factor 1-induced monocyte differentiation into macrophages." in: Biochimica et biophysica acta, Vol. 1833, Issue 8, pp. 1936-46, (2013) (PubMed).

Latasa, Ituero, Moran-Gonzalez, Aranda, Cosgaya: "Retinoic acid regulates myelin formation in the peripheral nervous system." in: Glia, Vol. 58, Issue 12, pp. 1451-64, (2010) (PubMed).

Target Details for EGR2

Target: EGR2 (Early Growth Response 2 (EGR2))

Alternative Name: EGR2

Background:

Background Information: The early growth response protein 2 (EGR2) is a transcription factor with three tandem C2H2-type zinc fingers. Mutations in this gene are associated with the autosomal dominant Charcot-Marie-Tooth disease, type 1.The early growth response protein 2 is a transcription factor with three tandem C2H2-type zinc fingers. Mutations in this gene are associated with the autosomal dominant Charcot-Marie-Tooth disease, type 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Early growth response 2

Alternative Symbols: CHN1, AT591, CMT1D, CMT4E, KROX20

Protein Name: E3 SUMO-protein ligase EGR2

Molecular Weight: 50kDa

Gene ID: 1959

NCBI Accession: NP_000390

UniProt: P11161